1,331 results found
    1. Developmental Biology

    Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice

    Yu Shi, Fanxin Long
    Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance and insulin sensitivity in adult mice.
    1. Neuroscience

    Preoptic leptin signaling modulates energy balance independent of body temperature regulation

    Sangho Yu et al.
    The preoptic area (POA) regulates distinct metabolic adaptations, via leptin-dependent (fasting-induced hypometabolism and high-fat-diet-induced hypermetabolism), or leptin-independent mechanisms (temperature induced metabolic changes) and thus significantly contributes to body weight homeostasis.
    1. Neuroscience

    CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

    Penelope Dimas et al.
    Endogenous synthesis of fatty acids by oligodendrocytes is essential for development and repair in the central nervous system.
    1. Genetics and Genomics
    2. Neuroscience

    Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

    Yehudit Hasin-Brumshtein et al.
    In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.
    1. Cell Biology

    An alternative splicing program promotes adipose tissue thermogenesis

    Santiago Vernia et al.
    NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

    Meredith A Sommars et al.
    B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang et al.
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Cell Biology
    2. Human Biology and Medicine

    Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

    Martina Rudnicki et al.
    Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Population Genetics: Why structure matters

    Nick Barton et al.
    Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.
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    1. Neuroscience

    Amyotrophic Lateral Sclerosis: Marking the differences in motoneurons

    Simon A Sharples, Patrick J Whelan
    A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
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