2,019 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

    James W Opzoomer, Jessica A Timms ... Shahram Kordasti
    ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.
    1. Physics of Living Systems

    Emergence of behaviour in a self-organized living matter network

    Philipp Fleig, Mirna Kramar ... Karen Alim
    Behavioural states emerge from variability in the complexity of underlying active contraction dynamics in a single-cell, network-shaped forager.
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Computational and Systems Biology

    Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

    Zhenghao Chen, Anil Raj ... Adam Freund
    A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.
    1. Physics of Living Systems

    Dynamics of cooperative excavation in ant and robot collectives

    S Ganga Prasath, Souvik Mandal ... L Mahadevan
    Observations of ant excavation from a confining corral, along with theoretical models and synthetic robot experiments show the emergence of cooperation induced by pheromones in a malleable environment that is moulded by and moulds collective behavior.
    1. Microbiology and Infectious Disease

    Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

    Lesia Semenova, Yingfan Wang ... Edward P Browne
    Dimension reduction and machine learning tools were used to identify novel associations between the HIV reservoir and the immune systems of people with HIV.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu, Ri-Qi Su ... Xiao Wang
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-dimensional electron crystallography of protein microcrystals

    Dan Shi, Brent L Nannenga ... Tamir Gonen
    A new electron diffraction technique called MicroED allows protein structures to be determined from three-dimensional microcrystals.
    1. Developmental Biology

    Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining

    Wentao Yu, Lei Kang ... Terence TW Wong
    TRUST, as a rapid and fully automated whole-organ imaging technique, enables high-resolution multicolor 3D imaging at low cost by using a UV-LED for widefield illumination and a color camera while relieving researchers from lengthy and laborious tissue processing protocols.
    1. Physics of Living Systems
    2. Immunology and Inflammation

    Early life imprints the hierarchy of T cell clone sizes

    Mario U Gaimann, Maximilian Nguyen ... Andreas Mayer
    The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.

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