103 results found
    1. Immunology and Inflammation

    High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node

    Szandor Simmons et al.
    Impairment of the autocrine S1PR1-Gi signaling on HEVs results in high-endothelial cell apoptosis, reduced CCL21-secretion from HEVs, and cessation of HEV-DC interactions and lymphocyte immigration across the high-endothelial barrier.
    1. Immunology and Inflammation

    Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α

    Yu-Tung Li et al.
    Blood flow-driven shear forces guide the sequential signaling of two antagonistic paired receptors, a critical bi-facet step that first supports leukocyte docking, then initiates transmigration through endothelium.
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong et al.
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Neuroscience

    Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

    Mette Mathiesen Janiurek et al.
    Shortage of blood-borne apolipoprotein-M–bound sphingosine-1-phosphate, which accompanies various brain disorders, causes paracellular leak and increase in transcytosis at the blood–brain barrier, which can be reversed, thus is of clinical relevance.
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.
    1. Developmental Biology
    2. Immunology and Inflammation

    Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

    Federico Andrea Moretti et al.
    T cell progenitor homing into the thymus requires kindlin-3 to stabilize their adhesion to vascular integrin ligands when blood flow velocities and shear rates increase during development.
    1. Computational and Systems Biology
    2. Developmental Biology

    Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

    Benedetta Ubezio et al.
    Increasing levels of the growth factor Vegfa disrupt blood vessel branching morphogenesis and drive diameter increase by synchronizing Notch signalling fluctuations between endothelial cells.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

    Amy W Ku et al.
    Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.
    1. Cell Biology

    Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

    Fergus M O'Farrell et al.
    Lack of reperfusion of cardiac capillaries, when an upstream artery is unblocked following heart attack, reflects contractile pericytes constricting capillaries and preventing blood flow, implying that cardiac pericytes are a therapeutic target for treating cardiac ischaemia.

Refine your results by:

Type
Research categories