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A massively parallel reporter assay, mSTARR-seq, reveals widespread DNA methylation-environment interactions across the genome, prioritizing CpG sites identified in epigenome-wide association studies that may be most relevant to biological embedding.

TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.

Feathered feet of pigeons and chickens result from a partial molecular and morphological transformation of legs to a wing-like identity.

Sodium-activated potassium ion currents encoded by the kcnt1 gene delay action potential firing in DRG neurons by activity preceding an action potential.

All steps of a viroid-like replication cycle can be catalyzed by RNA alone.

Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.

The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.

Single-cell transcriptomes of larval zebrafish whole brain shed light on the multidimensional landscapes of transcription factors and post-transcriptional regulators in vertebrate whole-brain neuronal classification and revealed principles of how neuronal cell diversity develops and evolves.

An innovative inter-subject stimulus-locked brain activation approach uncovers marked topological differences in a brain network of higher-order visual regions in individuals with a congenital impairment in face recognition compared with controls.

After domestication, the cultivation range expansion of crops was not solely dictated by human activity but instead constrained by climatic factors, which in turn resulted in distinct phenotypic characteristics of locally adaptive landraces.