Scratch-AID, a deep learning-based system for automatic quantification of mouse scratching behavior, could replace labor-intensive manual quantification and facilitate high through-put anti-itch drug screening.
Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
Guangliang Wang, Surendra K Rajpurohit ... Jeff S Mumm
A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.
Helena Brezovjakova, Chris Tomlinson ... Vania MM Braga
Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
APEX2 proximity labeling of genetically targeted neurons enables subcellular and cell type-specific proteomics in the mouse brain, revealing the axonal and somatodendritic proteomes of midbrain dopaminergic neurons.
Theodore J Zwang, Rachel E Bennett ... Bradley T Hyman
Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.
The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.
