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    1. Ecology

    Testosterone pulses paired with a location induce a place preference to the nest of a monogamous mouse under field conditions

    Radmila Petric, Matina Kalcounis-Rueppell, Catherine A Marler
    Transient increases in the hormone testosterone shift behavioral focus by influencing both spatial preference and vocalizations of a monogamous and biparental mouse in the wild.
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai, Qun Liu ... Filippo Mancia
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Cell Biology
    2. Neuroscience

    Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

    Christian Keine, Mohammed Al-Yaari ... Samuel M Young Jr
    A combination of genetic, electrophysiological, and modeling approaches reveals that presynaptic Rac1 is a key molecule that controls synaptic strength and plasticity by regulating the synaptic vesicle cycle steps controlling the number of fusion competent synaptic vesicles.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

    Ramasubramanian Sundaramoorthy, Amanda L Hughes ... Tom Owen-Hughes
    Structural models of the chromatin remodeling enzyme Chd1 in solution and when bound to chromatin indicate that conformational changes to both the enzyme and the nucleosome occur upon nucleotide dependent engagement.
    1. Ecology

    Ant colonies maintain social homeostasis in the face of decreased density

    Andreas P Modlmeier, Ewan Colman ... David P Hughes
    Organizational resilience allows ant colonies to retain high interaction rates in the face of decreased density by altering their spatial and social dynamics.
    1. Structural Biology and Molecular Biophysics

    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

    Jun-ichi Kishikawa, Atsuko Nakanishi ... Ken Yokoyama
    Cryo-EM structures of rotary V-ATPase reveal the ON-OFF switching mechanism of H+ translocation in the Vo membrane domain.
    1. Chromosomes and Gene Expression

    Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting

    Jiyu Wang, Jie Zhou ... Elizabeth J Grayhack
    An eukaryotic specific system cooperates with the ribosome quality control pathway to maintain the reading frame during translation of slowly translated sequences.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The Chd1 chromatin remodeler shifts hexasomes unidirectionally

    Robert F Levendosky, Anton Sabantsev ... Gregory D Bowman
    Oriented hexasomes can be generated using the Widom 601 positioning sequence, which enables straightforward production of nucleosomes with asymmetrically modified H2A/H2B dimers.
    1. Structural Biology and Molecular Biophysics

    Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

    Lukasz Wieteska, Saeid Shahidi, Anastasia Zhuravleva
    The molecular chaperone BIP from the endoplasmic reticulum is fine-tuned postranslationally through the thermodynamic and kinetic alterations in its conformational ensemble of functionally and structurally distinct physiological forms.
    1. Cancer Biology
    2. Cell Biology

    Augmin prevents merotelic attachments by promoting proper arrangement of bridging and kinetochore fibers

    Valentina Štimac, Isabella Koprivec ... Iva M Tolić
    STED microscopy of human mitotic spindles reveals how augmin-nucleated microtubules protect the cell from erroneous kinetochore-microtubule attachments and ensure a highly organized architecture of the spindle required for mitotic fidelity.