A novel mechanism for gating nociceptive sensory-motor behavior is identified in freely behaving rats using high-speed videography that is controlled by posture and modulated by opioid and non-opioid receptor-dependent processes.
Development of a fully automated pain scale using machine learning tools in computational neuroethology and creation of new software, reveals a robust circuit-dissection compatible platform for objective pain measurement.
Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
Output neurons in the mushroom body of the fruit fly brain encode the positive or negative survival value of stimuli, enabling insects to choose adaptive approach and avoidance behaviors through associative learning.
Cerebellar Purkinje cells represent movements via bidirectional linear changes in spike rate, and activity from single cells is sufficient to reconstruct kinematic changes during bouts of free whisking.