12,686 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

    Nicholas O Burton, Alexandra Willis ... Eric A Miska
    Intergenerational adaptations to stress play a critical role in organismal responses to changing environments and are largely lost or erased after one generation.
    1. Genetics and Genomics

    The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

    Karole N D'Orazio, Colin Chih-Chien Wu ... Rachel Green
    Cue2 is an endonuclease that cleaves mRNA in the A site of the lagging ribosome upon ribosome collision events.
    1. Cell Biology

    Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

    Fatima Tleiss, Martina Montanari ... C Leopold Kurz
    Bacterial location quantifications highlights how Drosophila melanogaster larvae discriminate bacteria to isolate and later eliminate pathogens in the anterior midgut through coordinated mechanisms involving reactive oxygen species (ROS) and antimicrobial peptides (AMPs).
    1. Cell Biology
    2. Developmental Biology

    Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
    Modulation of division plane rotation in proliferating chondrocytes determines the ratio of clusters and columns, which may support the multifunctional design of the growth plate.
    1. Neuroscience

    Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

    Li Fan, Yichao Lu ... Qiang Wu
    A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing

    Eric D Hoffer, Samuel Hong ... Christine M Dunham
    Chemical modifications near the tRNA anticodon and specific mRNA–tRNA pairs combine to control the ribosomal three-nucleotide mRNA reading frame, essential for the sequential addition of amino acids into polypeptide chains.
    1. Neuroscience

    Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

    Virginia E Hawkins, Ana C Takakura ... Daniel K Mulkey
    CO2/H+-dependent purinergic signaling by astrocytes provides specialized control of vascular tone in a brainstem respiratory center in a manner that contributes to respiratory behavior.
    1. Physics of Living Systems

    Structural basis for the preservation of a subset of topologically associating domains in interphase chromosomes upon cohesin depletion

    Davin Jeong, Guang Shi ... D Thirumalai
    The finding that deletion of the genome folding motor leaves a significant fraction of a key structural feature of chromosome at the single cell and ensemble level has been explained.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

    Marina Theodosiou, Moritz Widmaier ... Reinhard Fässler
    Kindlin-2 co-operates with talin to activate fibronectin-binding integrins on fibroblasts and subsequently induces cell spreading by recruiting paxillin to small, peripheral nascent adhesions.
    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal, Asuka Takeishi ... Piali Sengupta
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.

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