751 results found
    1. Genetics and Genomics
    2. Cancer Biology

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy K Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Medicine
    2. Neuroscience

    Cold induces brain region-selective cell activity-dependent lipid metabolism

    Hyeonyoung Min, Yale Y Yang, Yunlei Yang
    It is of significance in identifying temperature sensitive brain regions in brain energy metabolism, as which might provide potential targetable sites in the treatment of brain lipid metabolism-associated neurological disorders.
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

    Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus

    Julianna Locantore, Yijun Liu ... Michael Wallace
    Basal ganglia output from the entopeduncular nucleus to the lateral habenula is not required for performance in a probabilistic switching task that requires flexible action/outcome decision making.
    1. Neuroscience

    Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors

    Vincent Huson, Wade G Regehr
    Different glutamate receptors have specialized roles that allow cerebellar unipolar brush cells to transform realistic mossy fiber input patterns into a continuum of temporal responses.
    1. Structural Biology and Molecular Biophysics

    Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Neuroscience

    Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

    Viktor János Oláh, Jing Wu ... Matthew JM Rowan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections

    Masayuki Ono, Masaya Yamaguchi ... Shigetada Kawabata
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling

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