SLC35G1 is the first highly chloride-sensitive transporter localized on the basolateral membrane of intestinal epithelial cells, responsible for citrate absorption.

Engineered anion-conducting channelrhodopsins with enhanced red-light sensitivity and accelerated kinetics enable precise, low-intensity optical silencing of neurons, advancing optogenetic control in neuroscience research.

Inhibiyiton of the lysosomal chloride-proton antiporter ClC-7 by the signaling lipid PI(3,5)P2 is important for lysosomal pH maintenance and is disrupted by a disease-causing gain-of-function mutation.

Lysosomes are highly enriched in chloride, which is essential for their degradative function.

Sweet and umami taste receptors are capable of sensing chloride ions, a component of table salt other than the salty taste-inducing component, sodium ions, and induce preferable taste sensations such as sweet taste.

WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and structure.

Cation chloride cotransporter CCC1 has a central function in plant cells and is the missing ion efflux component of the transport circuit necessary to regulate pH in the lumen of the trans-Golgi-network/early endosome, the major cargo hub in plant cells.

Adapting bacteria to use an introduced metabolic pathway recapitulates natural mutations and offers a novel bioremediation strategy.

Parallel measurements of pH gradient and membrane potential at the single vesicle level have revealed that the synaptic vesicle acidification is initiated by removal of its clathrin coat, which blocks vesicular ATPase activity.

VRAC activation, observed with a FRET sensor of intracellular LRRC8-domains movement during gating and by fluorometry, requires plasma membrane localization and diacylglycerol signaling, but is independent of intracellular ionic strength.