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    1. Biochemistry and Chemical Biology

    A novel DNA primase-helicase pair encoded by SCCmec elements

    Aleksandra Bebel, Melissa A Walsh ... Phoebe A Rice
    SCCmec genomic islands encode a novel primase-helicase pair in which priming ability is conferred upon an A-family DNA polymerase domain by a novel protein cofactor.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity

    Nate Yoder, Eric Gouaux
    The amino terminus of acid-sensing ion channel 1a forms a reentrant 'loop' that frames the lower pore and harbors a conserved 'His-Gly' motif implicated in gating and ion selectivity mechanisms.
    1. Neuroscience

    Perception of social interaction compresses subjective duration in an oxytocin-dependent manner

    Rui Liu, Xiangyong Yuan ... Wen Zhou
    The subjective time of social interactions reflects one's autistic-like tendency and is critically mediated by oxytocin, indicating that time perception is ingrained with personality traits, which likely have neuroendocrine origins as per previous research.
  1. Cutting Edge: Using mobile sequencers in an academic classroom

    Sophie Zaaijer, Columbia University Ubiquitous Genomics 2015 class, Yaniv Erlich
    A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.
    1. Neuroscience

    Neural mechanisms of social learning in the female mouse

    Yuan Gao, Carl Budlong ... Ian G Davison
    After mating, female mice form a sensory memory of the stud male's pheromones that correlates with striking changes in responsiveness of the specific neural ensemble activated by her partner.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Erasable labeling of neuronal activity using a reversible calcium marker

    Fern Sha, Ahmed S Abdelfattah ... Eric R Schreiter
    Protein engineering of a reversibly switchable fluorescent protein enables post-hoc reversible and repeatable marking of elevated calcium concentrations using blue light.
    1. Genetics and Genomics

    Differing isoforms of the cobalamin binding photoreceptor AerR oppositely regulate photosystem expression

    Haruki Yamamoto, Mingxu Fang ... Carl E Bauer
    A novel B12 containing photoreceptor is synthesized as two different isoforms that interact with the same transcription factor, with one isoform directing activation and the other promoting repression of photosystem synthesis.
    1. Neuroscience

    Capturing the temporal evolution of choice across prefrontal cortex

    Laurence T Hunt, Timothy EJ Behrens ... Steven W Kennerley
    Experiments in macaques and humans reveal time-varying changes in prefrontal cortex activity that occur during decisions based on costs and benefits.
  2. Line drawing of a human figure sitting on a stylised brain, in front of white sparks on a purple magenta background. Vicky Bowskill (CC BY-NC-ND 4.0)

    Being Neurodivergent in Academia: Autistic and abroad

    Andrew K Schulz
    An AuDHD researcher recounts the highs and lows of relocating to Germany for his postdoc.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments

    Didi He, Sam Hughes ... Jon Marles-Wright
    Encapsulin-associated ferritin proteins form metal-dependent decamers that are active as ferroxidase enzymes, but require encapsulation to form an iron store.