Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.

BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.

TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.

A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.

Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.

Plasma membrane clusters of the Parkinson's disease protein α-synuclein colocalize with negatively charged phospholipids involved in endocytosis and exocytosis.

The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).

Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.

Metabolites, such as acylcarnitines, accumulate in Drosophila heads when endocytosis is blocked and reflects an increased need for sleep.