233 results found
    1. Cell Biology

    Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

    Shekhar Srivastava et al.
    The mammalian potassium channel KCa3.1, which is important for T- and B-cell activation, is inhibited by cytoplasmic copper, mediated by a histidine residue (His358) that is phosphorylated to activate the channel.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

    Felipe Trajtenberg et al.
    The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.
    1. Cell Biology
    2. Genetics and Genomics

    The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

    Heather P Harding et al.
    Genetic lesions that compromise the ribosome P-stalk implicate direct signalling from the ribosome to the translation initiation factor eIF2 kinase GCN2 in the cellular response to amino acid starvation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway

    Anna M Puszynska, Erin K O'Shea
    The circadian clock of Synechococcus elongatus PCC7942 schedules the activity of the transcription factor RpaA, which controls key events in carbon metabolism that contribute to cell fitness in conditions mimicking the natural environment.
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai et al.
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Discovery of a metabolic alternative to the classical mevalonate pathway

    Nikki Dellas et al.
    A combination of phylogenetic and biochemical analyses suggest that some unexpected variations in the synthesis of isoprenoids may be widespread across all three domains of life.
    1. Microbiology and Infectious Disease

    c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility

    Bridget R Kulasekara et al.
    Real time measurements of c-di-GMP in individual cells reveal an unexpected mechanism by which the chemotaxis machinery controls c-di-GMP heterogeneity, thereby regulating flagellar-based motility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado et al.
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.
    1. Immunology and Inflammation

    IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

    Qian Wang et al.
    Osteoarthritis pathogenesis is driven by IgE-mediated mast cell activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

    Yvonne Vercoulen et al.
    The Ras activator RasGRP1 that impacts Ras signals in immune cells, leukemias, and colorectal cancer, switches to an active conformation aided by a pH-sensitive histidine residue in a central location of the RasGRP1 molecule.

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