202 results found
    1. Microbiology and Infectious Disease

    Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

    Fabien Sindikubwabo et al.
    A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

    Paul Victor Sauer et al.
    The CAF1 complex binds single histone H3-H4 dimers, and two such complexes associate with extended DNA elements to ensure the deposition of H3-H4 tetramers, the first step in the assembly of nucleosomes.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones

    Wallace H Liu et al.
    Biophysical and biochemical approaches reveal new insights into the architecture of CAF-1 and the unique mechanism by which CAF-1 tetramerizes histones H3/H4.
    1. Structural Biology and Molecular Biophysics

    Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123

    Sojin An et al.
    Structural and biochemical studies of Kap123 revealed the mechanisms by which Kap123 recognizes H3- and H4-NLSs through two lysine-binding pockets and by which evolutionarily conserved diacetylation of H4-NLS facilitates Kap123-H3-NLS mediated nuclear translocation.
    1. Cell Biology

    Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology

    Rohini R Nair et al.
    Prokaryotes use polycistronic messages for coordinated translation, whereas eukaryotic cells may achieve tunable protein synthesis by packaging monocistronic mRNAs into functional multiplexes via co-transcriptional interallelic coupling and non-canonical histone-H4 functions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

    Johanna Ludwigsen et al.
    The N-terminal domain of the chromatin remodeler ISWI contains previously uncharacterized conserved motifs that maintain structure, prevent ATP hydrolysis unless nucleosomes are bound, and confer H4-tail sensitivity without directly competing with the H4 tail.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication

    Francesca Mattiroli et al.
    After DNA replication, nucleosomes are assembled by two histone chaperone complexes each bound to an H3-H4 histone dimer, suggesting the feasibility for a semi-conservative mode of epigenome inheritance.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

    Yu-Xuan Lu et al.
    Modulation of histone levels in gut enterocytes by rapamycin treatment alters chromatin organisation and induces intestinal autophagy through transcriptional regulation to prevent age-related decline in the intestine and extend lifespan.
    1. Chromosomes and Gene Expression

    Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription

    Zhen Zhou et al.
    A yeast genetic model for studying the function of sister histones in chromatin dynamics.
    1. Chromosomes and Gene Expression

    Epigenetic memory independent of symmetric histone inheritance

    Daniel S Saxton, Jasper Rine
    Reduced fidelity of histone inheritance has minimal effects on inheritance of epigenetic states of heterochromatin in Saccharomyces..

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