Chemically sumoylated histone H4 shows negative biochemical crosstalk with gene-activating histone acetylation and methylation marks, and directly inhibits RNA polymerase II-mediated gene transcription.

A novel system for expression of asymmetric nucleosomes in vivo enables mechanistic studies on histone modification readouts in the cell.

Clr4, a highly conserved SUV39 histone methyltransferase, requires its SET domain to sense histone H3K14 ubiquitination in order to maintain heterochromatin and H3K9 methylation.

A yeast genetic model for studying the function of sister histones in chromatin dynamics.

Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.

The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.

Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the Ino80 subunit.

Nucleosome binding by PRC2 threads H3K27 into its active site via an interaction network set in register by unmodified H3K36.

Histone H3T11 phosphorylation regulates chronological lifespan by linking nutritional stress-response signals to chromatin.

The acetylation of histones at specific sites close to DNA can regulate transcription.