141 results found
    1. Structural Biology and Molecular Biophysics

    Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

    Cheng Dong et al.
    Complex structures of Tudor domains of PHF1/19 with H3tK27me3 provide structural basis for preferential recognition of H3tK27me3 over canonical H3K27me3, implicating that H3tK27me3 might be a physiological ligand of PHF1/19.
    1. Biochemistry and Chemical Biology

    Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

    Sara M Nowinski et al.
    Mitochondrial fatty acid synthesis is best known for producing lipoic acid, however, longer acyl chain products regulate mitochondrial electron transport chain assembly, oxidative TCA cycle metabolism, and skeletal myoblast differentiation.
    1. Cell Biology

    ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

    Chaitanya A Kulkarni et al.
    Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.
    1. Chromosomes and Gene Expression

    Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins

    Steven Z DeLuca et al.
    Characterization of Drosophila female germ cell differentiation shows that nurse cells initiate Polycomb silencing by regulating Pcl and Scm levels to alter the biochemical properties of the PRC2 H3K27 methylase.
    1. Cancer Biology

    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

    Joana G Marques et al.
    In fusion-positive rhabdomyosarcoma, CHD4 positively regulates super-enhancer-mediated gene expression by allowing a chromatin architecture at these cis-regulatory regions, which is permissive to the binding of the transcription factor PAX3-FOXO1.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    S-phase-independent silencing establishment in Saccharomyces cerevisiae

    Davis Goodnight, Jasper Rine
    Cell-cycle progression is crucial for heterochromatin formation in budding yeast because S phase promotes the removal of active chromatin marks.
    1. Medicine

    Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

    Tiziana Squillaro et al.
    An update on the role of lncRNAs in adipogenesis and adipose tissue function, aimed at promoting the identification of new drug targets for obesity and metabolic diseases.
    1. Biochemistry and Chemical Biology

    Diverse nucleosome Site-Selectivity among histone deacetylase complexes

    Zhipeng A Wang et al.
    By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

    Gernot Wolf et al.
    Unbiased ChIP-seq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRAB-ZFP) clusters reveal that evolutionarily young KRAB-ZFPs play a redundant role in retrotransposon restriction in mice.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin

    Gergana Shipkovenska et al.
    Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.

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