1,573 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

    Lenno Krenning, Stijn Sonneveld, Marvin E Tanenbaum
    mRNA decay contributes to reshape the transcriptome as a parent cell divides into daughter cells.
    1. Developmental Biology

    Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development

    Pénélope Tignard, Karen Pottin ... Marie Anne Breau
    Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.
    1. Chromosomes and Gene Expression

    Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

    Xinyang Bing, Wenfan Ke ... James B Jaynes
    Boundary:boundary pairing interactions drive TAD formation in Drosophila.
    1. Cell Biology
    2. Developmental Biology

    Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection

    Parvathy Ramesh, Nidhi Sharma Dey ... Lolitika Mandal
    Ecdysone-mediated regulation of Relish expression and activation in the hematopoietic niche is essential for progenitor maintenance in the Drosophila Lymph gland.
    1. Cancer Biology
    2. Computational and Systems Biology

    Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

    Andrew R Lynch, Nicholas L Arp ... Mark E Burkard
    Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin, Charisse Petersen ... B Brett Finlay
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle, Maximilian Nguyen, Jeremy Gunawardena
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.
    1. Developmental Biology

    CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans

    Benjamin P Weaver, Rebecca Zabinsky ... Min Han
    A broadly used gene expression regulatory mechanism inactivates targets by CED-3-caspase-mediated proteolysis and works in parallel to miRNAs for diverse non-apoptotic developmental functions.
    1. Microbiology and Infectious Disease

    Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

    Vivian Salgueiro, Jorge Bertol ... Rafael Prados-Rosales
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing

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