738 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

    Ilaria Pettinati et al.
    MBLAC1 is an endoribonuclease specific for replication dependent histone pre-mRNA processing during S-phase and may represent a new type of cancer target.
    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat

    Martin Reichard, Matej Polačik
    The turquoise killifish from ephemeral pools in African savannah combines extremely short lifespan with a standard vertebrate body plan – ideal attributes for a laboratory animal.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

    Jan Janouškovec et al.
    Apicomplexan-like parasites originated several times independently and many of them contain cryptic plastid organelles, which demonstrate that the parasites evolved from photosynthetic algae.
    1. Human Biology and Medicine

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li et al.
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

    Konstadinos Moissoglu et al.
    RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity

    Chen Qiu et al.
    A Caenorhabitis elegans RNA-binding protein, FBF-2, modulates RNA sequence motif recognition through conformational change and partner protein interaction.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan et al.
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

    Carlos Gorbea et al.
    iRICC, a new method to identify RNA-RNA interactions in vivo, provides mechanistic insight into the function of a viral non-coding RNA.

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