6,916 results found
    1. Immunology and Inflammation

    Macrophages regulate gastrointestinal motility through complement component 1q

    Mihir Pendse, Haley De Selle ... Lora V Hooper
    Gut macrophages produce complement component C1q, which modulates neurogenic activity of gut peristalsis and is thus a key regulator of gastrointestinal motility.
    1. Cell Biology
    2. Plant Biology

    The Arabidopsis SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the plasma membrane

    Alexis Lebecq, Mehdi Doumane ... Marie-Cécile Caillaud
    SAC9 prevents the accumulation of PI(4,5)P2 in intracellular compartments, thereby contributing to clathrin-mediated endocytosis at the plasma membrane and regulating the cortical localization of its protein partner SH3P2.
    1. Computational and Systems Biology
    2. Neuroscience

    Place-cell capacity and volatility with grid-like inputs

    Man Yi Yim, Lorenzo A Sadun ... Thibaud Taillefumier
    A very large number of place-field maps can be robustly learned by association of external cues with the grid-driven response, however plasticity in the grid-cell inputs renders the place-cell responses volatile.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm, Florian Schmid ... Albrecht Stroh
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.
    1. Cell Biology
    2. Neuroscience

    Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

    Yang Niu, Zhonghua Dai ... Jia-Jia Liu
    SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.
    1. Neuroscience

    The value of initiating a pursuit in temporal decision-making

    Elissa Sutlief, Charlie Walters ... Marshall G Hussain Shuler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics
    3. Cell Biology
    Plasma membrane going around a banner with two different kinases and one affecting the nucleus/cell cycle. Phosphates are dotted in the background

    Special Issue: Allosteric Regulation of Kinase Activity

    Edited by Volker Dötsch et al.
    Our latest Special Issue brings together research on the allosteric regulation of kinase activity.
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan Shugarts, Aishwarya Sathya ... Antony M Jose
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid

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