4,109 results found
    1. Structural Biology and Molecular Biophysics

    Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

    Andrew J Borst et al.
    An integrative structural and biophysical workflow indicates engagement of VRC01 germline antibodies can occur with a gp120 426c core construct containing all wild-type N-linked glycosylation sites, including the Asn276 glycan.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

    Xiaofei Jia et al.
    HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.
    1. Immunology and Inflammation

    The HIV-1 latent reservoir is largely sensitive to circulating T cells

    Joanna A Warren et al.
    HIV-specific T cells remain detectable for years in HIV-infected individuals on antiretroviral therapy and importantly, mostly (68%) recognize HIV viruses that have the capacity to rebound following treatment interruption.
    1. Microbiology and Infectious Disease

    Establishment and stability of the latent HIV-1 DNA reservoir

    Johanna Brodin et al.
    Building on previous work (Zanini et al, 2015), deep-sequencing is used to show that HIV persistence during suppressive antiretroviral therapy, the main hurdle for HIV cure, is due to homeostatic proliferation and longevity of infected cells rather than ongoing virus replication.
    1. Structural Biology and Molecular Biophysics

    Semen amyloids participate in spermatozoa selection and clearance

    Nadia R Roan et al.
    Ex vivo characterization of the interaction of human sperm with semen factors reveals that semen amyloids, previously discovered due to their ability to enhance HIV infection, serve a physiological function by promoting disposal of the defective sperm.
    1. Medicine
    2. Microbiology and Infectious Disease

    HIV-1 DNA predicts disease progression and post-treatment virological control

    James P Williams et al.
    Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
    1. Microbiology and Infectious Disease

    Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

    Eva Malatinkova et al.
    An early start to long-term antiretroviral therapy limits the size of the HIV-1 reservoir more effectively than treatment that starts later.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global divergence in critical income for adult and childhood survival: analyses of mortality using Michaelis–Menten

    Ryan J Hum et al.
    A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Immunology and Inflammation

    Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

    Cécile Alanio et al.
    Naïve CD8+ T cells are dysregulated during chronic hepatitis C (HCV) infection, and this is reversible after viral clearance.

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