209 results found
    1. Developmental Biology
    2. Neuroscience

    Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

    Mizuki Kurashina et al.
    Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.
    1. Neuroscience

    Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

    Ken Sugino et al.
    A transcriptome dataset of nearly 200 genetically identified mouse neuronal cell types revealed that short low-noise homeobox transcription factors and long neuronal effector genes best distinguish neuronal cell types.
    1. Developmental Biology
    2. Plant Biology

    Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems

    Benoît Landrein et al.
    Mechanical stress promotes the expression of the homeobox gene and meristem master regulator STM, synergistically and independently from auxin depletion.
    1. Neuroscience

    Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep

    Juliane Schwarz, Henrik Bringmann
    A genetic analysis has identified the cholinergic SIA sublateral motor neurons, which innervate all four body wall muscles separately, as crucial regulators of turning around during sleep in Caenorhabditis elegans.
    1. Neuroscience

    The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

    Emily G Berghoff et al.
    Circuit transcription factors may define the differentiation and assembly of distinct neurons into functional circuitry.
    1. Developmental Biology
    2. Neuroscience

    Regulation of retinal axon growth by secreted Vax1 homeodomain protein

    Namsuk Kim et al.
    Secreted Vax1 homeodomain protein supports the development of optic chiasm by directly acting at the retinal ganglion cell axon.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Information content differentiates enhancers from silencers in mouse photoreceptors

    Ryan Z Friedman et al.
    Silencers and enhancers targeted by a common transcription factor in photoreceptors are distinguished by the number and diversity of binding transcription factor binding sites they contain.
    1. Developmental Biology

    Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6

    Fang Yuan et al.
    Inducing expression of a single transcription factor LIM homeobox 6 showed efficient generation of human parvalbumin and somatostatin interneurons.
    1. Developmental Biology

    Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome

    Tian Yu et al.
    Mutations in CHD7, which cause CHARGE syndrome, cause a reduction in FGF8 signalling and subsequent abnormalities in the cerebellar vermis in both mice and humans.
    1. Developmental Biology
    2. Evolutionary Biology

    Maternally regulated gastrulation as a source of variation contributing to cavefish forebrain evolution

    Jorge Torres-Paz et al.
    Phenotypic evolution can originate from variations in very precocious developmental events, starting even before fecundation, during the fabrication of the egg in the mother's gonad.

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