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Interplay between protein concentration, DNA binding and remodeling of the chromatin landscape in early embryogenesis determines how a single transcription factor can specify multiple distinct gene expression states.

The epistasis observed in TF-DNA binding preferences can be explained by the presence of two optima of very similar Gibbs energy that are located relatively far from each other in sequence space.

Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.

Rescue of DUX4-induced muscle pathology by the RET inhibitor Sunitinib reveals the therapeutic potential for treatment of Facioscapulohumeral muscular dystrophy using tyrosine kinase inhibitors.

While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.

The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.

Gamete-derived three-amino-acid-loop-extension homeodomain proteins activate zygote development in a strikingly similar manner between basal land plants and green algae, indicating an ancestral role of these transcription factors in green plants.

The transcriptomes of individual cells of the 1- to 102-cell stages in Caenorhabditis elegans embryogenesis are identified along with 119 embryonic cell states during cell fate specification, including ‘equivalence-group’ cell identities.

Differential binding kinetics of a master regulator to its target promoters can prevent spontaneous cell fate loss in a Caenorhabditis elegans neuron whose fate is controlled by a reversible switch.