1,685 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection

    Bryan L Gitschlag et al.
    Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Neuroscience

    Dynamic encoding of social threat and spatial context in the hypothalamus

    Piotr Krzywkowski et al.
    Threat and context-responsive neurons in the ventromedial hypothalamus are reshaped by experience to drive social avoidance.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers et al.
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Neuroscience

    Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

    Javier Díaz-Alonso et al.
    Despite being the key element of the classic model for excitatory synaptic plasticity, the cytoplasmic AMPA receptor C-tail is not required for hippocampal LTP.
    1. Computational and Systems Biology

    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

    Anusorn Mudla et al.
    Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
    1. Cell Biology

    WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity

    Emmanuelle Steib et al.
    Centriole integrity is ensured by the connection between the inner scaffold and microtubule triplets through POC16/WDR90 proteins.

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