1,871 results found
    1. Chromosomes and Gene Expression

    Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

    Darpan Medhi et al.
    Different homologous recombination pathways are dominant in different regions of meiotic chromosomes, indicating that chromosome structure influences recombination biochemistry.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

    Yeonee Seol et al.
    The rate of DNA unwinding by RecQ helicases is dramatically modulated by the DNA duplex stability in a geometry-dependent manner, providing an intrinsic mechanism for suppressing illegitimate recombination.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

    Martijn S Luijsterburg et al.
    A new mechanism is uncovered by which the RNF168 ubiquitin ligase couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Protein Evolution: Building bigger beta-barrels

    Vikas Nanda
    The range of barrel-shaped proteins found in the outer membrane of certain bacteria evolved through multiple pathways.
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    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Chromosomes and Gene Expression

    DNA Replication: A new role for a tumor-suppressing protein

    Jeremy S Setton, Simon N Powell
    In addition to its role in preventing tumors, the protein p53 appears to participate in a DNA repair process known as the replication-stress response.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Tuberculosis: Breaking down walls

    Moagi Tube Shaku, Bavesh Davandra Kana
    A better understanding of the mechanisms underpinning the growth of mycobacteria could help identify targets for new antibiotics.
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