2,311 results found
    1. Cell Biology
    2. Developmental Biology

    Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

    Yan Xiong et al.
    Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
    1. Chromosomes and Gene Expression

    Bisulfite treatment and single-molecule real-time sequencing reveal D-loop length, position, and distribution

    Shanaya Shital Shah et al.
    D-loops are critical intermediates in homologous recombination, and the novel D-loop mapping assay defines position, length, and distribution of D-loops with near base-pair resolution.
    1. Chromosomes and Gene Expression

    Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length

    Shanaya Shital Shah et al.
    The dsDNA-dependent motor protein Rdh54 antagonizes Rad51-Rad54-mediated D-loop formation during homologous recombination and restricts the length of D-loops.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

    David Melamed, Daniel Kalderon
    Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Biochemistry and Chemical Biology

    Talin-activated vinculin interacts with branched actin networks to initiate bundles

    Rajaa Boujemaa-Paterski et al.
    At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The deubiquitylase Ubp15 couples transcription to mRNA export

    Fanny Eyboulet et al.
    Ubp15 regulates the ubiquitylation of the export adaptor Mex67.
    1. Structural Biology and Molecular Biophysics

    A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

    Priscilla S-W Yeung et al.
    Electrophysiological and molecular modeling studies identify a sulfur-aromatic interaction between the hydrophobic channel gate and a nearby methionine residue, termed the "gate latch", which is essential for Orai1 pore opening.
    1. Cell Biology
    2. Plant Biology

    Photosynthetic sea slugs induce protective changes to the light reactions of the chloroplasts they steal from algae

    Vesa Havurinne, Esa Tyystjärvi
    Slug chloroplasts avoid damage to photosynthesis by maintaining an oxidized electron transfer chain with the help of oxygen-sensitive electron acceptors.
    1. Cell Biology
    2. Developmental Biology

    Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

    Jamie C Little et al.
    Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.

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