Naomi J Petela, Andres Gonzalez Llamazares ... Kim A Nasmyth
First evidence of cohesin folding occurring in vivo and during cohesion together with a detailed description of the structural aspects of cohesin's elbow folding through a series of novel structures.
Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
Niklas Lonnemann, Shirin Hosseini ... Martin Korte
Expression of an interleukin that is immune suppressive (IL-37) in mice is able to limit inflammation in the brain after acute inflammatory events and prevent loss of cognitive abilities in a mouse model of AD.
Yuki Tanimoto, Akiko Yamazoe-Umemoto ... Koutarou D Kimura
A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
Peter Zatka-Haas, Nicholas A Steinmetz ... Kenneth D Harris
Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.
M Regina Scarpin, Samuel Leiboff, Jacob O Brunkard
Plants and humans use a shared mechanism, the eukaryotic metabolic sensor TARGET OF RAPAMYCIN protein kinase and its substrate, an RNA-binding protein called LARP1, to coordinate post-transcriptional gene expression.
Joaquín Letelier, Lorena Buono ... Juan R Martínez-Morales
Depletion of vsx genes in zebrafish confirms a conserved role in bipolar cells specification across vertebrates, but do not interfere with the formation of the neural retina domain, which reveal an unexpected robustness of the genetic network sustaining the retina.