165 results found
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
  1. Research: Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Kenneth D Gibbs Jr et al.
    A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

    Andrew James Kerr Conlan et al.
    Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Developmental Biology

    DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

    Sebastian Canovas et al.
    Reproductive fluids help the correct establishment of some epigenetic marks and gene expression in preimplantation pig embryos.
    1. Neuroscience

    Astrocyte morphology is confined by cortical functional boundaries in mammals ranging from mice to human

    Raya Eilam et al.
    The structural morphology of astrocyte processes is constrained by functional boundaries in the mouse, rat and human cortex.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov et al.
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
    1. Neuroscience

    Human blindsight is mediated by an intact geniculo-extrastriate pathway

    Sara Ajina et al.
    White matter microstructure in hemianopia patients indicates that blindsight requires an intact connection between the lateral geniculate nucleus and extrastriate cortex.
    1. Neuroscience

    Frequency-selective control of cortical and subcortical networks by central thalamus

    Jia Liu et al.
    Central thalamus relay neurons dynamically switch the activity of cortical and subcortical networks at distinct frequencies, providing a mechanism for this region's role in arousal regulation.

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