6,376 results found
    1. Microbiology and Infectious Disease

    A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

    Molly OhAinle et al.
    Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
    1. Plant Biology

    A host basal transcription factor is a key component for infection of rice by TALE-carrying bacteria

    Meng Yuan et al.
    Bacteria use the transcription factor binding region of their transcription activator-like effectors to hijack host basal transcription factor to cause rice diseases by activating host susceptibility genes.
    1. Microbiology and Infectious Disease

    pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

    Kenji Sugiyama et al.
    The host-derived factors, pp32 and APRIL, interact with influenza viral RNA polymerase to support viral genomic RNA synthesis from complementary RNA.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern et al.
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota density influences host physiology and is shaped by host and microbial factors

    Eduardo J Contijoch et al.
    The density of the gut microbiota influences the host immune system and adiposity, and can be therapeutically manipulated.
    1. Plant Biology

    A virus responds instantly to the presence of the vector on the host and forms transmission morphs

    Alexandre Martinière et al.
    Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.
    1. Computational and Systems Biology

    Cutting Edge: Anatomy of BioJS, an open source community for the life sciences

    Guy Yachdav et al.
    Community nurturing is the single most important factor in determining the sustainability of an open source project such as BioJS.
    1. Epidemiology and Global Health

    The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

    Michelle M Riehle et al.
    A common chromosome inversion in African malaria mosquito (Anopheles gambiae) is associated with differences in malaria infection, adult resting behavior and ecology, and may aid the most efficient vectors to evade malaria control.
    1. Developmental Biology

    Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

    Carine Gubelmann et al.
    A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Angiomotin functions in HIV-1 assembly and budding

    Gaelle Mercenne et al.
    Angiomotin (AMOT) is a cellular host factor that links HIV-1 to the ubiquitin E3 ligase, NEDD4L, and promotes virion assembly and envelopment.

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