Microbiome and transcriptomic profiling of genetically selected tropical fish with high and low tolerance to cold exposure revealed host control over microbiome composition and response to temperature changes.
Mutants of influenza A virus with increased CpG dinucleotide frequencies show restricted replication and reduced or absent pathogenicity, and powerful host innate and adaptive responses to infection that confer immunity to re-infection.
A novel virus-inclusive single cell RNA-Seq approach enables identification of novel pro- and antiviral host factors in human cells in response to dengue and Zika virus infection.
Defense-related selective autophagy mediated by the antimicrobial autophagy cargo receptor NBR1/Joka2 is diverted to pathogen penetration sites to restrict plant colonization by the oomycete pathogen Phytophthora infestans.
Directly targeting the ribosome to attenuate translation partly mimics the integrated stress response, increasing lifespan and preserving protein folding capacity even in older individuals with dysfunctional stress response signaling.
The RNA-binding protein, Zfp36, which is critical for resolving inflammation, inhibits the production of proinflammatory cytokines via modulation of the cytoplasmic poly(A)-binding protein.
A seminal protein from a mating-male can bind sperm previously stored in his mate, providing direct benefits to the sperm from the prior male that mated with her.
Two phosphorylation sites on 53BP1 are found to mediate interaction with TOPBP1-RAD9 and shown to be essential for assembling the G1 DNA damage checkpoint response apparatus.
A herpesvirus harnesses the unfolded protein response to regulate its own life cycle, revealing an unexpected role of XBP1u as a potent repressor of the most important viral promoter.
The inhibition of host Sirtuin-2 by AGK2 restricts mycobacterial growth in vivo by modulation of host transcriptome leading to activation of protective immune responses.
