1,441 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

    Jing Xue et al.
    Cryo-EM analysis of human ZnT8 reveals a large conformational change of TMD during the transport cycle.
    1. Neuroscience

    Disynaptic cerebrocerebellar pathways originating from multiple functionally distinct cortical areas

    Julia U Henschke, Janelle MP Pakan
    Anatomical projections from sensory, motor, and association cortex to the cerebellum are precisely mapped, including cortical-precerebellar connections and terminal organization, providing insight into how the cerebellum may utilize cortical information.
    1. Developmental Biology
    2. Genetics and Genomics

    An atlas of cell types in the mouse epididymis and vas deferens

    Vera D Rinaldi et al.
    A systematic survey of the epididymis identifies the cell types involved in post-testicular maturation of sperm.
    1. Computational and Systems Biology
    2. Developmental Biology

    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

    Bjoern Gaertner et al.
    Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.
    1. Microbiology and Infectious Disease

    MARCH8 inhibits viral infection by two different mechanisms

    Yanzhao Zhang et al.
    The host transmembrane protein MARCH8, previously known as an expression regulator of host proteins, is a powerful antiviral host factor with a potentially broad antiviral spectrum through two different mechanisms.
    1. Neuroscience

    Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks

    Víctor J López-Madrona et al.
    Integration and segregation of information of memory and sensory in the hippocampus could be achieved by the coordination of distinct theta-gamma coding frameworks.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING

    Sytse J Piersma et al.
    Cytomegaloviruses are recognized by distinct sensors depending on the infected cell type and together these sensors are essential for viral control and downstream immune responses.
    1. Structural Biology and Molecular Biophysics

    Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

    Sigrid Noreng et al.
    The in-depth structural and functional work provide a deeper understanding as to how the epithelial sodium channel is a heteromeric ion channel that is regulated by Na+ and proteolysis.
    1. Computational and Systems Biology
    2. Medicine

    A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

    Michael R Garvin et al.
    Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.
    1. Medicine
    2. Microbiology and Infectious Disease

    Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis

    Tyler Wagner et al.
    Applying deep learning technology for the large-scale curation of symptoms from unstructured EHR clinical notes accurately predicts the differential signals of COVID-19 diagnosis over the week preceding typical PCR testing.

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