Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.

CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.

A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.

Two zebrafish Keap1-paralogs are equally adept at electrophile-sensing but manifest divergent and co-regulatory electrophile-signaling behaviors.

Single-cell analysis of the chloroplast redox response to high light and oxidative stress revealed light-dependent heterogeneity, and was linked to cell fate determination within isogenic diatom populations.

The structural and pharmacological difference of the invertebrate counterpart of β-adrenergic receptor confers selective toxicity of an insecticide on honeybees and their devastating parasite Varroa mites.

Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.

The expansion of our understanding about the regulation of iron metabolism, erythropoiesis, and the crosstalk between them has enabled delineating the pathophysiology of multiple diseases and provided rationale for novel therapeutic interventions.