621 results found
    1. Microbiology and Infectious Disease

    Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

    Sukrit Silas, Patricia Lucas-Elio ... Antonio Sánchez-Amat
    Cooperation between evolutionarily disparate CRISPR-Cas modules allows bacteria to counter mutational escape by viruses.
    1. Cell Biology

    CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

    Jin Wang, Jiayi Xie ... Meng Zhao
    scRNA-seq identified CXCR4high MKs can funtionally regulate host-defense immune response against bacterial infection.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels

    Lizbeth Sayavedra, Manuel Kleiner ... Jillian M Petersen
    Beneficial symbiotic bacteria encode an exceptional number of toxin-related genes that are all expressed by the symbionts in the host, supporting their key role in host-microbe interactions.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants

    Panagiotis Sapountzis, Mariya Zhukova ... Jacobus J Boomsma
    Domestication of endosymbiotic Mollicutes may have resolved nitrogen-recycling challenges for attine ants and enabled the evolutionary derived leaf-cutting ants to fully exploit their herbivorous niches.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    CoCoNuTs are a diverse subclass of Type IV restriction systems predicted to target RNA

    Ryan T Bell, Harutyun Sahakyan ... Eugene V Koonin
    Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of a counter-defense mechanism in a virus constrains its host range

    Sriram Srikant, Chantal K Guegler, Michael T Laub
    Bacteriophage can rapidly evolve resistance to anti-phage defense elements in bacteria by amplifying latent counter-defense genes, though this amplification comes at a cost of compensatory deletions that eliminate other counter-defense genes.
    1. Plant Biology

    Pathogen effectors and plant immunity determine specialization of the blast fungus to rice subspecies

    Jingjing Liao, Huichuan Huang ... Jean-Benoit Morel
    Specialized fungal pathogen populations infect rice varieties with contrasting immune systems co-cultivated in a traditional agro-system, indicating the relevance of crop diversity to restricting epidemics in the landscape.
    1. Plant Biology

    Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis

    Alicia Kairouani, Dominique Pontier ... Thierry Lagrange
    Musashi-mediated post-transcriptional mechanisms regulate glucuronoxylan modification and secondary cell wall formation in the supportive fibre cells of stem in plants.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

    Jingxiang Li, Shupan Guo ... Haiyan Ren
    Transient interactions between NleE and PMSD10 suppress PSMD10 interaction with ATG7 to attenuate host autophagosome formation.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense

    Claudia Castillo-González, Xiuying Liu ... Xiuren Zhang
    A viral protein hijacks the key effector of transcriptional gene silencing, Su(var)3-9, to evade host plant surveillance.

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