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    1. Medicine

    Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

    Rebecca C Schugar, Christy M Gliniak ... Jonathan Mark Brown
    Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana

    Nyasha Charura, Ernesto Llamas ... Alga Zuccaro
    Programmed cell death during plant development (dPCD) is crucial for Arabidopsis thaliana root defense, limiting microbial invasion and maintaining a balanced relationship with beneficial microbes.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs

    Leah Guthrie, Sarah Wolfson, Libusha Kelly
    A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of microbiome metabolic phenotypes that shape human biology.
    1. Ecology

    Engineering multifunctional rhizosphere probiotics using consortia of Bacillus amyloliquefaciens transposon insertion mutants

    Jingxuan Li, Chunlan Yang ... Zhong Wei
    Increasing the intra-species phenotypic diversity of a plant-beneficial bacterium effectively improves probiotic consortium functioning and plant growth promotion in agricultural systems.
    1. Genetics and Genomics

    Plant Microbiome: How hungry roots get their microbes

    Maggie R Wagner
    Maize genes influence which species of bacteria are recruited from the soil, especially in the absence of nitrogen supplied by fertilizer.
    Version of Record
    Insight
    1. Ecology
    2. Microbiology and Infectious Disease

    Universal gut microbial relationships in the gut microbiome of wild baboons

    Kimberly E Roche, Johannes R Bjork ... Elizabeth A Archie
    In baboon gut microbiota, most pairwise correlations in bacterial abundances are weak and negative, and bacterial correlation patterns are largely shared across hosts, rather than personalized to each hosts.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Computer-guided design of optimal microbial consortia for immune system modulation

    Richard R Stein, Takeshi Tanoue ... Vanni Bucci
    A computational method is presented that quantifies the effect that specific bacteria in the gut have on the immune system and guides the design of therapeutically potent microbial consortia to cure auto-immune disease.
    1. Plant Biology

    Distinct effects of phyllosphere and rhizosphere microbes on invader Ageratina adenophora during its early life stages

    Zhao-Ying Zeng, Jun-Rong Huang ... Han-Bo Zhang
    An inoculation experiment shows phyllosphere microbiome plays an important role in invader Ageratina adenophora population establishment by killing seedlings at very early growth stage.
    1. Microbiology and Infectious Disease

    Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

    Anne L Sapiro, Beth M Hayes ... Seemay Chou
    Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild

    Ayumi Mure, Yuki Sugiura ... Yukako Hattori
    The growth of wild Drosophila larvae on fruits is promoted by a yeast releasing essential nutrients extracellularly or by a stable association with a nutrient-providing bacterium established by microbe–microbe interactions.