Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.

In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.

A multiplexed microfluidic device was developed to facilitate high-throughput screening of bacterial chemotaxis on a single chip and demonstrated across a range of microbes, chemostimulants, and chemical gradient conditions.

Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.

BoNT intoxication of neurons is revisited using a genome-wide siRNA screen and organelle-specific reporters, suggesting a mechanism of translocation to the cytosol fundamentally different than previously proposed.

A systematical study of pslG mutants at both a single cell and community level reveals the importance of intracellular glycosyl hydrolase PslG on the cell fate and biofilm development of P. aeruginosa, an opportunistic pathogen that can cause persistent infections.

One minute biotinylation with APEX2 peroxidase in living cells identifies established and new components of mitochondrial and ER membranes; dataset intersection and overexpression screen identifies SYNJ2BP overexpression as inducing mitochondria-rough ER contacts.

A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.

An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.