668 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density

    Ellie Sherrard-Smith et al.
    Combining pre-erythrocytic and transmission blocking antibodies enhances the overall control and potential elimination of malaria within both mosquito and vertebrate populations.
    1. Biochemistry and Chemical Biology

    The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

    Tyler B Faust et al.
    The HIV-1 Tat protein hijacks host non-degradative ubiquitination to trigger the nuclear import of the transcription elongation factor, P-TEFb.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

    Joana A Santos et al.
    ECF-CbrT is a bacterial vitamin B12 transporter that is structurally different from the well-characterized transporter BtuCDF, yet has similar functional properties.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity

    Jun Qin et al.
    Genetic and biochemical analyses reveal a virulence mechanism employed by V. dahliae that involves inhibition of the transcription factor activity of CBP60g and SARD1.
    1. Immunology and Inflammation

    Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

    Jie Geng et al.
    HLA-B*35:01 molecules that are peptide-deficient are thermostable, bind CD8 with higher affinity than their peptide-filled versions, accumulate at immunological synapses and enhance antigen-specific CD8+ T cell immune responses.
    1. Cell Biology

    A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells

    Ewelina Betleja et al.
    Cells have evolved a mechanism that actively regulates centriole maturation during quiescence.
    1. Cancer Biology
    2. Cell Biology

    The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation

    Nomeda Girnius et al.
    Mutational inactivation of the JNK signaling pathway causes genomic instability and breast cancer development.
    1. Cell Biology
    2. Neuroscience

    Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

    Craig S Pearson et al.
    4-sulfation at the non-reducing end of chondroitin sulfate glycosaminoglycan chains is essential for inhibition of axonal growth.
    1. Microbiology and Infectious Disease
    2. Genetics and Genomics

    Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii

    Sarah L Sokol et al.
    A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
    1. Human Biology and Medicine
    2. Neuroscience

    A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

    Poh Hui Chia et al.
    A biallelic missense mutation in the highly conserved, neuron-specific kinase CAMK2A abrogates holoenzyme assembly and causes a new inherited neurodevelopmental disease.

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