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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

    Masahiro Oka, Sonoko Mura ... Yasuyuki Ohkawa
    A key molecule that connects leukemogenic proteins to aberrant HOX gene regulation turned out to be a nuclear export factor, CRM1.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen, Wen-Fu Hsieh ... Jun-An Chen
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Developmental Biology
    2. Genetics and Genomics

    Disparate expression specificities coded by a shared Hox-C enhancer

    Steve W Miller, James W Posakony
    Tucked within a well-known story of diverging gene function is a single enhancer encoding two inseparable specificities that regulates two adjacent genes, each with different spatiotemporal expression patterns.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

    Antigoni Gogolou, Celine Souilhol ... Anestis Tsakiridis
    A thorough insight into the previously unrecognised role of a critical developmental regulator known as TBXT in influencing the specification of human trunk neural crest cells, the presumed precursors of the childhood tumour neuroblastoma.
    1. Neuroscience

    An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons

    Paschalis Kratsios, Sze Yen Kerk ... Oliver Hobert
    Genetic analysis reveals the mechanistic basis of motor neuron subclass specification in Caenorhabditis elegans.
    1. Developmental Biology

    A complex regulatory landscape involved in the development of mammalian external genitals

    Ana Rita Amândio, Lucille Lopez-Delisle ... Denis Duboule
    In vertebrates, large regulatory landscapes sometimes behave as coherent regulatory units, which may explain the lack of effect sometimes observed when single enhancer sequences are deleted in isolation.
    1. Computational and Systems Biology
    2. Developmental Biology

    A re-inducible gap gene cascade patterns the anterior–posterior axis of insects in a threshold-free fashion

    Alena Boos, Jutta Distler ... Ezzat El-Sherif
    The body axis of insects is divided into different fates using a self-regulatory and threshold-free mechanism.
    1. Developmental Biology

    An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

    Aubrey GA Howard IV, Phillip A Baker ... Rosa A Uribe
    Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Cis-regulatory modes of Ultrabithorax inactivation in butterfly forewings

    Amruta Tendolkar, Anyi Mazo-Vargas ... Arnaud Martin
    CRISPR knock-outs and functional genomic approaches probe the regulatory mechanism restricting the Hox gene Ubx to butterfly hindwings, explaining color pattern differentiation from forewings.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A transcriptome atlas of leg muscles from healthy human volunteers reveals molecular and cellular signatures associated with muscle location

    Tooba Abbassi-Daloii, Salma el Abdellaoui ... Vered Raz
    Molecular atlas of Human leg muscles molecular atlas reveals muscle-specific signatures that discriminate between muscle groups.