The identification of key determinants of LSC “stemness” and LSC differentiation that is reversible through an epigenetic mechanism may have considerable implications in understanding leukemia and designing effective therapies.

Based on benchmarking various methods and analyzing multiple real scRNA-seq datasets, a computational platform/workflow and a set of tips for best practices are developed for analyzing causal interactions or relationships in single cells.

UV irradiation, a major cause of skin damage, leads to selective loss of fibroblasts from the upper dermis via a deregulated inflammatory response, and infiltrating T cells can promote fibroblast survival in UV irradiated skin.

Alternative splicing of multiple apoptotic genes is enhanced by CD28 costimulation to promote cell survival.

Linker histones affect the lineage determination of granulocyte precursor cells via regulation of the transcription factor GATA-2.

Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.

DynAPs are liquid-like organelles that are partitioned into functional sub-domains.

Partial copy loss of spliceosome genes are common non-driver gene dependencies in cancer.

Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.

Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.