3,911 results found
    1. Neuroscience

    Increasing adult-born neurons protects mice from epilepsy

    Swati Jain, John J LaFrancois ... Helen E Scharfman
    Increasing adult-born neurons in the dentate gyrus reduces neuronal loss and chronic seizures in female mice using a mouse model of temporal lobe epilepsy.
    1. Developmental Biology

    Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

    Jingqiang Wang, Chunye Liu ... Yi Arial Zeng
    Genetic and mechanistic analyses reveal how ovulatory rupture triggers the activation and expansion of ovarian surface epithelial stem/progenitor cells, through selective activation of Yap, and enhanced expression of Procr by Yap.
    1. Immunology and Inflammation

    Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

    Rhoanne C McPherson, Joanne E Konkel ... Stephen M Anderton
    Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.
    1. Cell Biology

    C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

    Yuu Miyazaki, Atsuhiko Ichimura ... Hiroshi Takeshima
    Membrane potential adjustment required for growth plate chondrocytic signal conversion from cGMP to Ca2+ influx toward long bone outgrowth.
    1. Neuroscience

    Transcranial magnetic stimulation (TMS) inhibits cortical dendrites

    Sean C Murphy, Lucy M Palmer ... Matthew E Larkum
    Studying the activity of cortical neurons in rats reveals the subcellular effects of transcranial magnetic stimulation, which is used for the non-invasive treatment of a variety of brain disorders.
    1. Stem Cells and Regenerative Medicine

    Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: A pre-clinical systematic review

    Chintan Dave, Shirley HJ Mei ... Lauralyn McIntyre
    Administration of cryopreserved as compared freshly cultured MSCs do not appear to negatively impact measures of in vivo efficacy or in vitro potency in animal models of inflammation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

    Xiaowen Liu, Thuy Vien ... David E Clapham
    The primary cilia polycystin proteins, polycystin-1 and polycystin-2, affect cilia length in the kidney collecting duct epithelia, but only polycystin-2 is required for the functional ion channel in this organelle.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang, Thomas A Hughes ... Sriram Neelamegham
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Cancer Biology

    Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

    Lan-Feng Dong, Jaromira Kovarova ... Jiri Neuzil
    A genetic approach documents that mitochondrial DNA moves from donor cells to recipient mtDNA-depleted cells in whole mitochondria and that this restores mitochondrial respiration and the capacity of the cells to form tumours.
    1. Microbiology and Infectious Disease

    Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

    Lianhua Qin, Junfang Xu ... Haipeng Liu
    Galectin-9 directly binds to arabinogalactan (AG), leading to the identification of AG-specific monoclonal antibodies that effectively inhibit Mycobacterium tuberculosis growth, providing insights for novel tuberculosis therapies.

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