Browse the search results

Page 2 of 117
    1. Epidemiology and Global Health

    Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study

    Gayathri Nagaraj, Shaveta Vinayak ... Dimpy P Shah
    Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.
    1. Neuroscience

    Inferring control objectives in a virtual balancing task in humans and monkeys

    Mohsen Sadeghi, Reza Sharif Razavian ... Dagmar Sternad
    A virtual balancing task with parallel experiments on human and non-human primates revealed a spectrum of behaviors (classified by a computational model into position, velocity, or mixed control strategy) that can serve as basis for analyzing neural population dynamics.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan, Anthony K Redmond ... Timothy Read
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Stem Cells and Regenerative Medicine

    Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

    Saleh Omairi, Antonios Matsakas ... Ketan Patel
    The concepts that oxidative muscle fibres cannot be large and that satellite cell number is the major determinant for effective regeneration are fundamentally challenged.
    1. Neuroscience

    NINscope, a versatile miniscope for multi-region circuit investigations

    Andres de Groot, Bastijn JG van den Boom ... Tycho M Hoogland
    A light-weight, compact and open-source miniaturized fluorescence microscope integrates dual region brain imaging, optogenetic stimulation and behavioral parsing using an accelerometer.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The lingering effects of Neanderthal introgression on human complex traits

    Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
    Genetic variants introgressed into modern humans from Neanderthals tend to be depleted in their contribution to heritable trait variation relative to modern human variants consistent with the action of purifying selection.
    1. Cancer Biology

    Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

    Jiangfei Chen, Kunal Baxi ... Myron S Ignatius
    Zebrafish are an optimal model organism to study rare TP53 mutations whose functions are not readily understood.
    1. Cancer Biology

    BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

    Paul Huchede, Swann Meyer ... Marie Castets
    BMP2 and 7 synergize with H3.3K27M epigenetic context to establish a quiescent but invasive state in pediatric diffuse midline gliomas.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MEMO1 binds iron and modulates iron homeostasis in cancer cells

    Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
    Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.
    1. Neuroscience

    Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

    Pablo M Casillas-Espinosa, Alison Anderson ... Terence J O'Brien
    Sodium selenate is the first treatment with persistent disease-modifying effects reducing seizures and improving cognitive deficits, in chronically epileptic and drug-resistant TLE animals.