A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.

Human cell lines regress to become ‘de-sexualized’ by reconfiguring to a 2:3 X/A ratio of high fitness, thus shedding light on the evolution of mammalian sex chromosomes.

The combination of ceritinib with CGM097 demonstrates remarkable antitumor activity in TP53 wild-type neuroblastoma models with ALK aberrations and is able to overcome the resistance acquired during ceritinib treatment.

Human cell lines replicate and proliferate without ORC1 or ORC2, two subunits of the replication initiator protein complex ORC, which has till now been considered essential for DNA replication.

The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.

Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.

Linker histones affect the lineage determination of granulocyte precursor cells via regulation of the transcription factor GATA-2.

In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.

Two modes of actin polymerization, branched and linear, cooperate in B cells to extract antigens from surfaces of presenting cells.

Endogenous double-stranded RNA is generated in human cells and leads to RNase L activation and consequent cell death unless neutralized by adenosine deaminase acting on RNA1 (ADAR1).