The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.

The human Origin Replication Complex is shaped as a shallow corkscrew in a classic AAA+ organization reminiscent of clamp loader complexes with highly controlled ATPase activity as exemplified by Meier-Gorlin syndrome mutations.

A dynamic and hierarchical sequence of steps in human frontal cortex orchestrates cognitive control.

In vivo quantitative analysis of multi-shell diffusion MRI reveals novel insights into microstructure of human insular cortex and its functional circuits associated with the salience network and cognitive control.

The sleep-deprived brain in humans undergoes upscaled intracortical excitability which diminishes induction of LTP-like plasticity via transcranial electrical stimulation while converting the LTD-like to LTP-like plasticity and these physiological changes couple with impaired learning, memory, and attention at behavioral level.

Structural, biochemical, and proteomic analyses of a four-subunit core module of the cleavage and polyadenylation specificity factor complex reveal its molecular architecture and specific determinants of polyadenylation signal recognition in human mRNAs.

The structure of a human antibody in which the variable loops position a human protein LAIR1 for antigen recognition, reveals a novel and indirect mode of antibody function.

High-resolution structures of human TRPM2 in different functional states provided the mechanism underlying ligand recognition, channel activation and inhibition.

Data-driven and effective connectivity analyses reveal patterns of functional specialization, common mechanisms, and brain-wide interaction profiles within the human inferior parietal lobes for multiple functional domains.

Songbirds can use arbitrary visual cues to immediately, flexibly and adaptively control syntax of learned song vocalizations in a manner that parallels human cognitive control over syllable sequencing in speech.