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8,144 results found
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese et al.
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Neuroscience

    Oxytocin promotes coordinated out-group attack during intergroup conflict in humans

    Hejing Zhang et al.
    Humans intranasally administered the neuropeptide oxytocin waste less and earn more spoils during intergroup conflict because oxytocin enables group members to better coordinate strategic attacking of out-groups.
    1. Microbiology and Infectious Disease

    The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria

    Sara C Di Rienzi et al.
    Melainabacteria, a candidate phylum related to Cyanobacteria, has been identified in gut and sediment samples by genomic analysis.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs

    Leah Guthrie et al.
    A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of microbiome metabolic phenotypes that shape human biology.
    1. Microbiology and Infectious Disease

    Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

    Aaron G Wexler et al.
    The human gut bacterial lipoprotein BtuG binds vitamin B12 with femtomolar affinity, can remove vitamin B12 from human intrinsic factor, and is required for commensal fitness in the gut.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Chromosomes and Gene Expression

    Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

    Nina Kirstein et al.
    Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.
    1. Microbiology and Infectious Disease

    MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

    Martial Marbouty et al.
    Physical contacts of bacteria and phage genomes allow in situ exploration of underdocumented phage families in the gut.
    1. Chromosomes and Gene Expression

    An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

    Peter J Skene, Steven Henikoff
    CUT&RUN (Cleavage Under Targets & Release Using Nuclease) profiles antibody-targeted DNA-binding proteins in situ with high resolution and low background, providing a simple, robust and scalable alternative to chromatin immunoprecipitation.
    1. Microbiology and Infectious Disease

    Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

    Nitzan Koppel et al.
    A unique, widely distributed gut bacterial enzyme selectively metabolizes plant-derived cardiac glycoside drugs.

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