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    1. Cell Biology
    2. Developmental Biology

    An in vitro stem cell model of human epiblast and yolk sac interaction

    Kirsty ML Mackinlay et al.
    Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome

    Georgia Panagiotakos et al.
    The Timothy syndrome mutation in Cav1.2 gives rise to defects in neuronal differentiation by preventing a developmental switch in channel splicing and elevating calcium signaling in differentiating cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation

    Daniel R Fuentes et al.
    A new approach combines guide RNA multiplexing with CRISPR activation and interference to facilitate functional studies of transposable elements present in hundreds of copies throughout the human genome.
    1. Stem Cells and Regenerative Medicine

    Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction

    Shir Toubiana et al.
    Correction of the DNA methyltransferase 3B gene in ICF1 syndrome fails to rescue the abnormal DNA hypomethylation at subtelomeric regions due to accompanied epigenetic abnormalities in these regions.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj et al.
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Neuroscience

    A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

    Yishan Sun et al.
    A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Engineering induction of singular neural rosette emergence within hPSC-derived tissues

    Gavin T Knight et al.
    A bioengineering approach identifies tissue morphology as an effective variable for controlling the inception of neural organoid morphogenesis via induction of a biomimetic, singular neural rosette tissue cytoarchitecture.
    1. Stem Cells and Regenerative Medicine

    In vitro generation of human pluripotent stem cell derived lung organoids

    Briana R Dye et al.
    Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm

    Arun Sharma et al.
    Analyses of human stem cells with distinct GATA6 mutations revealed a spectrum of molecular responses that drive isolated congenital heart disease or the co-occurrence of pancreas and diaphragm malformations.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy et al.
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.