371 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

    David Alejandro Bejarano et al.
    Interaction of HIV capsids with the cellular protein cleavage-and-polyadenylation factor 6 at the inner side of nuclear pores promotes nuclear entry of the viral replication complex in primary human macrophages.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

    Bridgette M Cumming et al.
    Quantifiable bioenergetic parameters, determined from extracellular flux analyses, are distinct between macrophages infected with Mycobacteriumtuberculosis or vaccine strain M. bovis BCG, enabling assessment of future vaccine and drug efficacy.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells

    Deeqa Mahamed et al.
    The rapid killing of macrophages by Mycobacterium tuberculosis aggregates, and the subsequent proliferation of the bacteria inside the dead cell, leads to a cell death cascade and explains the coupling of necrosis and pathogen growth observed in active disease.
    1. Chromosomes and Gene Expression

    p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

    Michal Krawczyk, Beverly M Emerson
    A long non-coding RNA removes the transcriptional repressor p50 to regulate recruitment of co-activator p300 and RNA Polymerase II complexes to activate the COX-2 gene in human mammary epithelial cells and macrophages.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Immunology: Identifying a nuclear passport for HIV

    Lorena Zuliani-Alvarez, Greg J Towers
    Identification of a protein that pulls HIV into the nucleus explains a key step in HIV infection.
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    1. Chromosomes and Gene Expression

    HIV: The two sides of Tat

    Matjaz Barboric, Koh Fujinaga
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    1. Immunology and Inflammation

    Autoimmunity: Treating type-1 diabetes with an epigenetic drug

    Yohko Kitagawa, Naganari Ohkura
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunodeficiency: Back from the brink of obscurity

    Donald C Vinh
    A mutation in a transcription factor makes people susceptible to Trophyrema whippelii, the bacterium that causes a rare condition called Whipple's disease.
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    1. Microbiology and Infectious Disease

    HIV-1 Latency: Coloring hidden viruses

    Marina Lusic
    An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
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