196 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

    Kenichi Shimada et al.
    shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo et al.
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

    Lavanya H Palavalli Parsons et al.
    PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Cancer Biology

    Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

    Bahman Afsari et al.
    A supervised methodology for mutational signatures outperforms the current standard unsupervised approach revealing new tissue-dependent mutational signatures among which some for obesity.
    1. Developmental Biology
    2. Genetics and Genomics

    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

    Ryan J Geusz et al.
    Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
    1. Cancer Biology

    The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

    Jacob T Polaski et al.
    UPF1 mutations were reportedly present at high frequencies in a cohort of pancreatic adenosquamous carcinoma patients, but these lesions are unlikely to be functional drivers of this cancer subtype.
    1. Developmental Biology

    Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

    Megan M Colonnetta et al.
    A molecular duel between germline and somatic determinants ensures proper establishment of transcriptional quiescence in the primordial germ cells of early Drosophila embryos.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Cancer Biology
    2. Cell Biology

    Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

    Shima Ghoroghi et al.
    A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.

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