4,612 results found
    1. Cell Biology
    2. Cancer Biology

    Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

    Seung-Hyun Ro et al.
    Sestrin2 loss could be a universal mechanism of human colon carcinogenesis that allows for barrier dysfunction, mTORC1 hyperactivation, unrestricted tumor growth and chemoresistance.
    1. Developmental Biology

    Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila

    Ashley C Humphries et al.
    Human neural tube closure defects associated mutations in planar cell polarity (PCP) genes are causative of the disease, as revealed in the intricate Drosophila PCP model.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Immunology and Inflammation

    Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

    Jose U Scher et al.
    The sequencing of microbial genomes reveals that the presence of a particular microbial species in the gut may increase the risk of the autoimmune disease rheumatoid arthritis.
    1. Cancer Biology

    Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

    Nicolai J Toft et al.
    Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.
    1. Cancer Biology
    2. Developmental Biology

    PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

    Genevieve C Kendall et al.
    The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.
    1. Microbiology and Infectious Disease

    Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

    Kevin J Forsberg et al.
    A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.
    1. Microbiology and Infectious Disease

    Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

    Elisa De Crignis et al.
    Human liver organoids provide a patient-derived platform to interrogate host and viral mechanisms of HBV replication, perform anti-HBV and toxicity drug screens, and investigate the molecular determinants of related tumorigenesis.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

    Ana J Caetano et al.
    Single cell transcriptomic analysis provides a reference map for human oral muscosa in health and disease and a framework for the development of new therapeutic strategies.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

    Nimisha Chaturvedi et al.
    Integrated analysis of IFN-λ and HCV amino acid variation indicates the key role of host innate immunity in viral control.

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