There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
Tanja Fuchsberger, Claudia Clopath ... Ole Paulsen
Neuronal reactivation during dopamine modulation induces input-specific LTP at previously primed hippocampal synapses, suggesting a possible solution to the credit assignment problem and a mechanism for memory linking.
Epilepsy caused by focal Pten deletion is only prevented when both mTOR complexes are simultaneously inhibited, but not alone, suggesting they play independent roles in the development of epilepsy.
Van Schepler-Luu, Coline Sciallano ... Wolf B Frommer
Discovery of a rapidly spreading outbreak of bacterial blight in Tanzania caused by a Xanthomonas strain that originates from Asia and editing of Komboka rice lines resistant to the newly introduced strains and to other Asian and African strains.
Peer-Hendrik Kuhn, Alessio Vittorio Colombo ... Stefan F Lichtenthaler
The metalloprotease ADAM10 modulates axon and synapse function by cleaving numerous synaptic and axonal membrane proteins in the central nervous system.
Jodie A Schiffer, Francesco A Servello ... Javier Apfeld
C. elegans nematodes use a sensory-neuronal circuit to determine whether to defend themselves from hydrogen peroxide attack or to freeload off orthologous protective defenses from bacteria in their surrounding environment.
Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.