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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pathway dynamics can delineate the sources of transcriptional noise in gene expression

    Lucy Ham, Marcel Jackson, Michael PH Stumpf
    There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
    1. Neuroscience

    Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs

    Tanja Fuchsberger, Claudia Clopath ... Ole Paulsen
    Neuronal reactivation during dopamine modulation induces input-specific LTP at previously primed hippocampal synapses, suggesting a possible solution to the credit assignment problem and a mechanism for memory linking.
    1. Neuroscience

    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

    Erin R Cullen, Mona Safari ... Matthew C Weston
    Epilepsy caused by focal Pten deletion is only prevented when both mTOR complexes are simultaneously inhibited, but not alone, suggesting they play independent roles in the development of epilepsy.
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    1. Microbiology and Infectious Disease

    Genome editing of an African elite rice variety confers resistance against endemic and emerging Xanthomonas oryzae pv. oryzae strains

    Van Schepler-Luu, Coline Sciallano ... Wolf B Frommer
    Discovery of a rapidly spreading outbreak of bacterial blight in Tanzania caused by a Xanthomonas strain that originates from Asia and editing of Komboka rice lines resistant to the newly introduced strains and to other Asian and African strains.
    1. Cell Biology
    2. Neuroscience

    Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

    Peer-Hendrik Kuhn, Alessio Vittorio Colombo ... Stefan F Lichtenthaler
    The metalloprotease ADAM10 modulates axon and synapse function by cleaving numerous synaptic and axonal membrane proteins in the central nervous system.
    1. Developmental Biology
    2. Neuroscience

    Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies

    Jodie A Schiffer, Francesco A Servello ... Javier Apfeld
    C. elegans nematodes use a sensory-neuronal circuit to determine whether to defend themselves from hydrogen peroxide attack or to freeload off orthologous protective defenses from bacteria in their surrounding environment.
    1. Microbiology and Infectious Disease

    Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

    Hui Li, Jun Yang ... Bo Peng
    Dysregulated unsaturated fatty acids and saturated fatty acids contribute to bacterial phenotypic resistance to antibiotics.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sweepstakes reproductive success via pervasive and recurrent selective sweeps

    Einar Árnason, Jere Koskela ... Bjarki Eldon
    Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
    1. Neuroscience

    High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling

    Peibo Xu, Jian Peng ... Yuejun Chen
    A multiplexed retrograde virus tracing method captures single-neuron projectome and transcriptome simultaneously.
    1. Neuroscience

    A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

    Andrew JP Fink, Richard Axel, Carl E Schoonover
    A naturalistic assay for head-fixed mice permits observation of a diverse set of innate and learned behaviors without requiring any training.