124 results found
    1. Immunology and Inflammation

    Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

    Xiaoting Wu et al.
    Inducible fate-mapping analysis demonstrates that neither microglia, CD11c+ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.
    1. Cancer Biology
    2. Medicine

    Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

    S Jordan Kerns et al.
    Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
    1. Biochemistry and Chemical Biology

    Tissue-specific targeting of DNA nanodevices in a multicellular living organism

    Kasturi Chakraborty et al.
    DNA nanodevices can be targeted to specific cell types in Caenorhabditis elegans with subcellular precision by exploiting either endogenous or synthetic receptors.
    1. Immunology and Inflammation

    Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

    Isobel C Mouat et al.
    Latent gammaherpesvirus infection predisposes mice to develop more severe disease following induction of arthritis by elevating pathogenic interferon-gamma-expressing age-associated B cells.
    1. Cancer Biology
    2. Physics of Living Systems

    Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

    Joshua D Greenlee et al.
    Oxaliplatin-resistant colorectal cancer cells exhibit unregulated death receptor 4 expression with increased receptor palmitoylation and translocation into lipid rafts, increasing their sensitivity to apoptosis via TRAIL.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

    Barbara H Stokes et al.
    Plasmodium falciparum K13 mutations confer resistance to the antimalarial artemisinin in Asian and African parasites, with most gene-edited mutant K13 African parasite lines showing a fitness cost that may predict slow dissemination of artemisinin resistance in high-transmission settings.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process

    Jimena Pérez-Vargas et al.
    The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.
    1. Microbiology and Infectious Disease

    Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

    Maria Eugenia Dieterle et al.
    Several previously proposed cell-surface receptors for hantaviruses could be deleted in endothelial cells with little or no effect on infection, indicating that critical hantavirus entry factors remain undiscovered.
    1. Cancer Biology

    Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

    M Ines Pascoal Ramos et al.
    NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction, might be a powerful new strategy for cancer immunotherapy for collagen-rich immune-excluded tumors.
    1. Genetics and Genomics

    Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy

    Hironori Uehara et al.
    Adenoviral CRISPR/Cas9 gene knockdown of mutant Col8a2 achieves structural and functional rescue of murine Fuchs’ endothelial corneal dystrophy, the first demonstration of post-mitotic CRISPR-based knockdown for phenotypic restoration.

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