606 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

    Sona Gregorova et al.
    Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility

    Liu Wang et al.
    The exogenous DNA DSBs improve meiotic chromosome pairing in mouse inter-subspecific hybrids, thus providing an evidence for a DSB-dependent mechanism of the PRDM9-controlled synapsis failure and infertility.
    1. Genetics and Genomics

    Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

    Leslie M Turner, Bettina Harr
    The genomic regions that cause male hybrids between house mouse subspecies to have low fertility have been identified.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast

    Sarah E Zanders et al.
    Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

    Colin D Meiklejohn et al.
    Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Computational and Systems Biology
    2. Neuroscience

    The head direction circuit of two insect species

    Ioannis Pisokas et al.
    Two evolutionary distant insect species share a common head direction circuit with subtle differences in neuronal morphologies that result in distinct circuit dynamics adapted to each species’ ecology.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls et al.
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    1. Cell Biology

    Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

    Kenji Sugioka et al.
    A genetic screen and live cell imaging show that a newly identified coiled-coil protein called SAS-7 is the earliest acting factor in centriole assembly yet identified in the roundworm Caenorhabditis elegans.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair et al.
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.

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