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    1. Genetics and Genomics

    Quantifying concordant genetic effects of de novo mutations on multiple disorders

    Hanmin Guo, Lin Hou ... Qiongshi Lu
    EncoreDNM identifies abundant enrichment correlations across disorders for de novo mutations.
    1. Neuroscience

    Predictive models for secondary epilepsy in patients with acute ischemic stroke within one year

    Jinxin Liu, Haoyue He ... Yongbing Deng
    Machine learning models effectively predict the risk of post-stroke epilepsy using extensive clinical data, offering new insights for improving patient management in clinical neurology.
    1. Neuroscience

    Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

    Jerome Robert, Emily B Button ... Cheryl L Wellington
    Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

    Doudou Wang, Ryo Nitta ... Nobutaka Hirokawa
    The structural and functional analysis demonstrates the mechanism of dual functional, motility and microtubule depolymerization in a unique motor, KIF19A.
    1. Neuroscience

    Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range

    Pál Barzó, Ildikó Szöts ... Gábor Tamás
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

    Virginia Folgado-Marco, Kristina Ames ... Nicholas E Baker
    The homozygous and heterozygous phenotypes of mouse Rps12 deletion are described, highlighting pancytopenia reflecting roles in hematopoiesis and erythropoiesis.
    1. Developmental Biology

    Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

    Eva Lana-Elola, Sheona Watson-Scales ... Victor LJ Tybulewicz
    A panel of seven new mouse strains with chromosomal duplications is used to identify a minimal genetic region required in three copies to cause congenital heart defects typical of human Down syndrome.
    1. Neuroscience

    Science Forum: What is next in African neuroscience?

    Kirsten A Donald, Mahmoud Maina ... Charles R Newton
    Working in Africa provides neuroscientists with opportunities that are not available in other continents, but obstacles must be overcome for the neuroscience community in Africa to reach its full potential.
    1. Microbiology and Infectious Disease

    A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

    Nguyen TH Mai, Nicholas Dobbs ... Guy E Thwaites
    Adjunctive aspirin may reduce new brain infarcts and deaths in the first 60 days of treatment for HIV-uninfected adults with tuberculous meningitis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function

    Samuel Dean, Flavia Moreira-Leite, Keith Gull
    Basalins are intrinsically disordered proteins with astonishingly high-sequence divergence that are essential for building the transition zone basal plate and for proper central pair nucleation.